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2326: Electron Density Reconstruction 48

Closed since over 2 years ago

Novice Overall Prediction Electron Density

Summary

Created
July 11, 2023
Expires
Max points
100
Description

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This puzzle has four chains in it, two of each type. Two have the sequence GIVEQCCTSICSLYQLENYCN and two have the sequence FVNQHLCGEHLVEALYLVCGERGFFYTPKT.

Top groups

  1. Avatar for SETI.Germany 11. SETI.Germany 1 pt. 19,013
  2. Avatar for A generic group 12. A generic group 1 pt. 18,950
  3. Avatar for AlphaFold 13. AlphaFold 1 pt. 18,674
  1. Avatar for Galaxie
    1. Galaxie Lv 1
    100 pts. 19,718
  2. Avatar for LociOiling 2. LociOiling Lv 1 94 pts. 19,715
  3. Avatar for Sandrix72 3. Sandrix72 Lv 1 87 pts. 19,708
  4. Avatar for NinjaGreg 4. NinjaGreg Lv 1 81 pts. 19,695
  5. Avatar for Bruno Kestemont 5. Bruno Kestemont Lv 1 76 pts. 19,685
  6. Avatar for Punzi Baker 3 6. Punzi Baker 3 Lv 1 70 pts. 19,682
  7. Avatar for grogar7 7. grogar7 Lv 1 65 pts. 19,682
  8. Avatar for BootsMcGraw 8. BootsMcGraw Lv 1 60 pts. 19,677
  9. Avatar for dcrwheeler 9. dcrwheeler Lv 1 56 pts. 19,674
  10. Avatar for christioanchauvin 10. christioanchauvin Lv 1 52 pts. 19,667

Comments

LociOiling Lv 1

PDB 1B9E, titled "HUMAN INSULIN MUTANT SERB9GLU" is a match for the protein in this puzzle.

The SERB9GLU part means the serine normally found at residue 9 in chain B has mutated to glutamate in this version of insulin.

The Foldit classic revisiting puzzle 58: Insulin Mutant also features an "insulin mutant", but it has serine at B9. The revisiting puzzle only has chains A and B, where puzzle 2326 also has C and D chains. Chain A has the same sequence as chain C, and chain B matches chain D.