Icon representing a puzzle

Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner

Summary

Created
May 07, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for CHEM1210/1020 TTU 11. CHEM1210/1020 TTU 1 pt. 11,753
  1. Avatar for BaD_DraKKo 221. BaD_DraKKo Lv 1 11 pts. 11,935
  2. Avatar for gamgyuriii 222. gamgyuriii Lv 1 10 pts. 11,926
  3. Avatar for lyxf88 223. lyxf88 Lv 1 10 pts. 11,919
  4. Avatar for hazog_ 224. hazog_ Lv 1 10 pts. 11,914
  5. Avatar for GFast 225. GFast Lv 1 10 pts. 11,911
  6. Avatar for ddnerd 226. ddnerd Lv 1 10 pts. 11,906
  7. Avatar for Frederino 227. Frederino Lv 1 10 pts. 11,903
  8. Avatar for kiron 228. kiron Lv 1 10 pts. 11,899
  9. Avatar for gediminasz 229. gediminasz Lv 1 10 pts. 11,897
  10. Avatar for gogolum 230. gogolum Lv 1 9 pts. 11,891

Comments