Icon representing a puzzle

Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner

Summary

Created
September 26, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Rechenkraft.net 11. Rechenkraft.net 1 pt. 11,894
  2. Avatar for UPJ Biochem 25 12. UPJ Biochem 25 1 pt. 11,753
  3. Avatar for ORIS 13. ORIS 1 pt. 11,753
  1. Avatar for zbc 341. zbc Lv 1 1 pt. 11,753
  2. Avatar for strannik 342. strannik Lv 1 1 pt. 11,753
  3. Avatar for Sora 343. Sora Lv 1 1 pt. 11,753
  4. Avatar for Ahikhoo 344. Ahikhoo Lv 1 1 pt. 11,753
  5. Avatar for ghostslider 345. ghostslider Lv 1 1 pt. 11,753
  6. Avatar for jodytate 346. jodytate Lv 1 1 pt. 11,753
  7. Avatar for moonlightae 347. moonlightae Lv 1 1 pt. 11,753
  8. Avatar for atris8326 348. atris8326 Lv 1 1 pt. 11,753
  9. Avatar for folditssmv7 349. folditssmv7 Lv 1 1 pt. 11,753
  10. Avatar for folditssmv2 350. folditssmv2 Lv 1 1 pt. 11,753

Comments