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Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner

Summary

Created
October 31, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for CHEM1210/1020 TTU 11. CHEM1210/1020 TTU 1 pt. 11,755
  2. Avatar for MikaB 12. MikaB 1 pt. 11,753
  3. Avatar for ahashanzhu_group 13. ahashanzhu_group 1 pt. 11,753
  1. Avatar for dege10 251. dege10 Lv 1 3 pts. 11,753
  2. Avatar for Ant505 252. Ant505 Lv 1 3 pts. 11,753
  3. Avatar for Berryberry 253. Berryberry Lv 1 2 pts. 11,753
  4. Avatar for mimi2222 254. mimi2222 Lv 1 2 pts. 11,753
  5. Avatar for jy 255. jy Lv 1 2 pts. 11,753
  6. Avatar for jmireles99 256. jmireles99 Lv 1 2 pts. 11,753
  7. Avatar for Zesstra 257. Zesstra Lv 1 3 pts. 11,753
  8. Avatar for hedel 258. hedel Lv 1 2 pts. 11,753
  9. Avatar for rakkarriya 259. rakkarriya Lv 1 2 pts. 11,753
  10. Avatar for ahazen 260. ahazen Lv 1 2 pts. 11,753

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