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Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner Beginner

Summary

Created
October 31, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for CHEM1210/1020 TTU 11. CHEM1210/1020 TTU 1 pt. 11,755
  2. Avatar for MikaB 12. MikaB 1 pt. 11,753
  3. Avatar for ahashanzhu_group 13. ahashanzhu_group 1 pt. 11,753
  1. Avatar for tazawa 261. tazawa Lv 1 2 pts. 11,753
  2. Avatar for afnanab 262. afnanab Lv 1 2 pts. 11,753
  3. Avatar for gnicole 263. gnicole Lv 1 2 pts. 11,753
  4. Avatar for skim245 264. skim245 Lv 1 3 pts. 11,753
  5. Avatar for Username.12345 265. Username.12345 Lv 1 2 pts. 11,753
  6. Avatar for lschaff 266. lschaff Lv 1 2 pts. 11,753
  7. Avatar for Yokomi 267. Yokomi Lv 1 3 pts. 11,753
  8. Avatar for reecesi 268. reecesi Lv 1 1 pt. 11,753
  9. Avatar for tjohnston714 269. tjohnston714 Lv 1 2 pts. 11,753
  10. Avatar for xuyilai_xia 270. xuyilai_xia Lv 1 2 pts. 11,753

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