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2604: Electron Density Reconstruction 116

Closed since 11 months ago

Novice Overall Prediction Electron Density

Summary

Created
April 23, 2025
Expires
Max points
100
Description

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This puzzle is fairly large with two copies of the protein, so we highly recommend using the Trim tool.

Sequence
TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAWSHPQFEK

Top groups

  1. Avatar for Intellectual decay of Brazil (IDEB) 11. Intellectual decay of Brazil (IDEB) 1 pt. 0
  1. Avatar for annekanestvogel 71. annekanestvogel Lv 1 1 pt. 19,551
  2. Avatar for Rato_Atomico87 72. Rato_Atomico87 Lv 1 1 pt. 0
  3. Avatar for MEYOT 73. MEYOT Lv 1 1 pt. 0

Comments

LociOiling Lv 1

This week's puzzle is a match for PDB 2Y4P, among others.

It's cheerfully described as a "DEATH-ASSOCIATED PROTEIN KINASE" in some entries, or just "DAP" in others.

Puzzle: 2604: Electron Density Reconstruction 116
segment count = 552
2 chains and ligands
chain A (protein), segments 1-276, length = 276
tvfrqenvddyydtgeelgsgqfavvkkcrekstglqyaakfikkrrtkssrrgvsredierevsilkeiqhpnvitlhevyenktdvililelvaggelfdflaekeslteeeateflkqilngvyylhslqiahfdlkpenimlldrnvpkprikiidfglahkidfgnefknifgtpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanvsavnyefedeyfsntsalakdfirrllvkdpkkrmtiqdslqhpwikp
chain B (protein), segments 277-552, length = 276
tvfrqenvddyydtgeelgsgqfavvkkcrekstglqyaakfikkrrtkssrrgvsredierevsilkeiqhpnvitlhevyenktdvililelvaggelfdflaekeslteeeateflkqilngvyylhslqiahfdlkpenimlldrnvpkprikiidfglahkidfgnefknifgtpefvapeivnyeplgleadmwsigvityillsgaspflgdtkqetlanvsavnyefedeyfsntsalakdfirrllvkdpkkrmtiqdslqhpwikp

(edit: provided better PDB link)