Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 6 months ago

Beginner

Summary

Created
August 28, 2025
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Mahmut Oyunda
    1. Mahmut Oyunda
    100 pts. 9,489
  2. Avatar for Go Science 2. Go Science 52 pts. 9,450
  3. Avatar for BearCorp 3. BearCorp 24 pts. 9,248
  4. Avatar for People team 4. People team 10 pts. 9,016
  5. Avatar for CBE_ProEn_2025 5. CBE_ProEn_2025 4 pts. 8,734
  6. Avatar for Coastal Biochemistry 6. Coastal Biochemistry 1 pt. 8,446
  7. Avatar for CH4110 Fold it! 7. CH4110 Fold it! 1 pt. 8,431
  8. Avatar for BIOL2020AB Fall2025 8. BIOL2020AB Fall2025 1 pt. 6,300
  9. Avatar for Columbia University CHEN4800 Protein Engineering Fall 2025 9. Columbia University CHEN4800 Protein Engineering Fall 2025 1 pt. 6,300
  1. Avatar for lolo588 51. lolo588 Lv 1 1 pt. 6,332
  2. Avatar for komekome 52. komekome Lv 1 1 pt. 6,313
  3. Avatar for Everestpinguin 53. Everestpinguin Lv 1 1 pt. 6,300
  4. Avatar for Utisha 54. Utisha Lv 1 1 pt. 6,300
  5. Avatar for draggitpurple 55. draggitpurple Lv 1 1 pt. 6,300
  6. Avatar for MA Yingtong 56. MA Yingtong Lv 1 1 pt. 6,300
  7. Avatar for phyooo 57. phyooo Lv 1 1 pt. 6,300
  8. Avatar for Red_Outcast 58. Red_Outcast Lv 1 1 pt. 6,300
  9. Avatar for saly5892 59. saly5892 Lv 1 1 pt. 6,300
  10. Avatar for fufokming 60. fufokming Lv 1 1 pt. 6,300

Comments