Placeholder image of a protein
Icon representing a puzzle

2684: Electron Density Reconstruction 143

Closed since 4 months ago

Novice Overall Prediction Electron Density

Summary

Created
October 29, 2025
Expires
Max points
100
Description

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

Sequence
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNEHHHHHH

Top groups

  1. Avatar for L'Alliance Francophone
    1. L'Alliance Francophone
    100 pts. 22,791
  2. Avatar for Go Science 2. Go Science 60 pts. 22,766
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 33 pts. 22,766
  4. Avatar for Contenders 4. Contenders 17 pts. 22,713
  5. Avatar for VeFold 5. VeFold 8 pts. 22,665
  6. Avatar for Australia 6. Australia 4 pts. 22,590
  7. Avatar for Marvin's bunch 7. Marvin's bunch 2 pts. 22,480
  8. Avatar for FamilyBarmettler 8. FamilyBarmettler 1 pt. 22,453
  9. Avatar for Void Crushers 9. Void Crushers 1 pt. 22,442
  10. Avatar for Gargleblasters 10. Gargleblasters 1 pt. 22,004
  1. Avatar for meatexplosion 21. meatexplosion Lv 1 20 pts. 22,465
  2. Avatar for BootsMcGraw 22. BootsMcGraw Lv 1 18 pts. 22,455
  3. Avatar for WBarme1234 23. WBarme1234 Lv 1 17 pts. 22,453
  4. Avatar for TheGUmmer 24. TheGUmmer Lv 1 15 pts. 22,442
  5. Avatar for westchuck 25. westchuck Lv 1 14 pts. 22,405
  6. Avatar for manu8170 26. manu8170 Lv 1 12 pts. 22,402
  7. Avatar for georg137 27. georg137 Lv 1 11 pts. 22,401
  8. Avatar for Anfinsen_slept_here 28. Anfinsen_slept_here Lv 1 10 pts. 22,388
  9. Avatar for NinjaGreg 29. NinjaGreg Lv 1 9 pts. 22,388
  10. Avatar for g_b 30. g_b Lv 1 8 pts. 22,386

Comments

LociOiling Lv 1

This week's puzzle is a good match for PDB 2B48.

The protein started life as a single chain, but a long section of residues went missing in the experimental results. PDB 2B48 is missing residues 25 to 81 mid-chain. This gap is what gives the appearance of two chains in the puzzle. PDB 2B48 is also missing residues at the end of the chain.

PDB 2B48 is a dimer, with two identical copies of the protein, both with the same missing residues. Puzzle 2684 has it as a monomer, with only one copy of the protein. Between the missing residues and the missing second copy of the protein, puzzle 2684 looks a little odd. It would make more sense if we had more pieces of the puzzle.

The protein is an apoptosis inhibitor, involved in regulating the process of programmed cell death or apoptosis.