Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 3 months ago

Beginner

Summary

Created
November 06, 2025
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Street Smarts
    1. Street Smarts
    100 pts. 9,519
  2. Avatar for Antharis Therapeutics 2. Antharis Therapeutics 56 pts. 9,413
  3. Avatar for Bioqué? 3. Bioqué? 29 pts. 9,398
  4. Avatar for Coastal Biochemistry 4. Coastal Biochemistry 14 pts. 9,270
  5. Avatar for CBE_ProEn_2025 5. CBE_ProEn_2025 6 pts. 9,205
  6. Avatar for Dr. House's team 6. Dr. House's team 2 pts. 9,191
  7. Avatar for Ubuntu 7. Ubuntu 1 pt. 9,161
  8. Avatar for People team 8. People team 1 pt. 8,351
  9. Avatar for CHEM1210/1020 TTU 9. CHEM1210/1020 TTU 1 pt. 8,307
  10. Avatar for Crosby Bio 222 F20 10. Crosby Bio 222 F20 1 pt. 6,331
  1. Avatar for moisex 101. moisex Lv 1 1 pt. 6,300
  2. Avatar for wuyeliming 102. wuyeliming Lv 1 1 pt. 6,300
  3. Avatar for ketijapujate 103. ketijapujate Lv 1 1 pt. 6,300
  4. Avatar for Agnese 104. Agnese Lv 1 1 pt. 6,300
  5. Avatar for tonya 105. tonya Lv 1 1 pt. 6,300
  6. Avatar for jarvislw 106. jarvislw Lv 1 1 pt. 6,300
  7. Avatar for y/n 107. y/n Lv 1 1 pt. 6,300
  8. Avatar for Hapleous 108. Hapleous Lv 1 1 pt. 6,300
  9. Avatar for Chengkun Fei 109. Chengkun Fei Lv 1 1 pt. 6,300
  10. Avatar for meyarsn6 110. meyarsn6 Lv 1 1 pt. 6,300

Comments