Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 3 months ago

Beginner

Summary

Created
November 06, 2025
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Street Smarts
    1. Street Smarts
    100 pts. 9,519
  2. Avatar for Antharis Therapeutics 2. Antharis Therapeutics 56 pts. 9,413
  3. Avatar for Bioqué? 3. Bioqué? 29 pts. 9,398
  4. Avatar for Coastal Biochemistry 4. Coastal Biochemistry 14 pts. 9,270
  5. Avatar for CBE_ProEn_2025 5. CBE_ProEn_2025 6 pts. 9,205
  6. Avatar for Dr. House's team 6. Dr. House's team 2 pts. 9,191
  7. Avatar for Ubuntu 7. Ubuntu 1 pt. 9,161
  8. Avatar for People team 8. People team 1 pt. 8,351
  9. Avatar for CHEM1210/1020 TTU 9. CHEM1210/1020 TTU 1 pt. 8,307
  10. Avatar for Crosby Bio 222 F20 10. Crosby Bio 222 F20 1 pt. 6,331
  1. Avatar for mako.king 11. mako.king Lv 1 63 pts. 9,326
  2. Avatar for Kooi 12. Kooi Lv 1 60 pts. 9,318
  3. Avatar for malia 13. malia Lv 1 57 pts. 9,314
  4. Avatar for Wildice1100 14. Wildice1100 Lv 1 54 pts. 9,308
  5. Avatar for Niorka 15. Niorka Lv 1 52 pts. 9,308
  6. Avatar for BeatriceGrace 16. BeatriceGrace Lv 1 49 pts. 9,301
  7. Avatar for akela.lankford 17. akela.lankford Lv 1 47 pts. 9,299
  8. Avatar for SamAG 18. SamAG Lv 1 44 pts. 9,278
  9. Avatar for milano0017 19. milano0017 Lv 1 42 pts. 9,273
  10. Avatar for machilde1 20. machilde1 Lv 1 40 pts. 9,270

Comments