Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 24 days ago

Beginner

Summary

Created
January 15, 2026
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 9,432
  2. Avatar for UIC_PSCI 2. UIC_PSCI 41 pts. 9,396
  3. Avatar for Street Smarts 3. Street Smarts 14 pts. 9,345
  4. Avatar for BIOF215 4. BIOF215 4 pts. 9,281
  5. Avatar for HEHE 5. HEHE 1 pt. 9,271
  6. Avatar for BIOTF345 6. BIOTF345 1 pt. 9,233
  7. Avatar for CBE_ProEn_2025 7. CBE_ProEn_2025 1 pt. 9,125
  1. Avatar for Madoka 81. Madoka Lv 1 1 pt. 6,300
  2. Avatar for AJ87 82. AJ87 Lv 1 1 pt. 6,300
  3. Avatar for Sanctuary 83. Sanctuary Lv 1 1 pt. 6,300
  4. Avatar for Thiennneneee 84. Thiennneneee Lv 1 1 pt. 6,300
  5. Avatar for sArA62 85. sArA62 Lv 1 1 pt. 6,300
  6. Avatar for catkins25 86. catkins25 Lv 1 1 pt. 6,300
  7. Avatar for eimoon 87. eimoon Lv 1 1 pt. 6,300
  8. Avatar for batovar 88. batovar Lv 1 1 pt. 6,300
  9. Avatar for hnhabli 89. hnhabli Lv 1 1 pt. 6,300
  10. Avatar for slampner 90. slampner Lv 1 1 pt. 6,300

Comments