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263: Alignment Freestyle

Closed since about 16 years ago

Intermediate

Summary


Created
February 23, 2010
Expires
Max points
100
Description

This is the first sequence alignment puzzle! You can choose "Show Alignment" from the Actions tab to use the new sequence alignment tool. See if you can find a better alignment than the starting one for this structure!

Top groups


  1. Avatar for Team China 11. Team China 2 pts. 9,214
  2. Avatar for SETI.Germany 12. SETI.Germany 1 pt. 9,161
  3. Avatar for ExPitneyFolders 13. ExPitneyFolders 1 pt. 8,971
  4. Avatar for sfb579 14. sfb579 1 pt. 8,965
  5. Avatar for Folders for Awesome 15. Folders for Awesome 1 pt. 8,591
  6. Avatar for Rechenkraft.net 16. Rechenkraft.net 1 pt. 8,527
  7. Avatar for Team South Africa 17. Team South Africa 1 pt. 8,514
  8. Avatar for Deleted group 18. Deleted group pts. 8,476
  9. Avatar for Ukraine 19. Ukraine 1 pt. 8,189

  1. Avatar for Bletchley Park
    1. Bletchley Park Lv 1
    100 pts. 9,505
  2. Avatar for Mark- 2. Mark- Lv 1 96 pts. 9,504
  3. Avatar for keypad5 3. keypad5 Lv 1 92 pts. 9,503
  4. Avatar for Madde 4. Madde Lv 1 88 pts. 9,497
  5. Avatar for TheGUmmer 5. TheGUmmer Lv 1 85 pts. 9,485
  6. Avatar for steveB 6. steveB Lv 1 81 pts. 9,482
  7. Avatar for HillObserver 7. HillObserver Lv 1 77 pts. 9,453
  8. Avatar for mimi 8. mimi Lv 1 74 pts. 9,453
  9. Avatar for Nicky666 9. Nicky666 Lv 1 71 pts. 9,447
  10. Avatar for calhoun 10. calhoun Lv 1 68 pts. 9,427

Comments


lilovip Lv 1

Let's look what alignment variants we actually have at this puzzle. It's easy to see there is only one place where we can play with alignment sequence: at the place of 2-aa size space. Changing at any other places will cause huge alignment points reduce. Known protein has the following aa sequence at that place:
SDSQND
And our protein has at start:
LSPxxE
So, now we can place two spaces within this six positions as we wish: they all will give 121 alignment points. I've tryed almost all of the variants. There is table of points for some of them (after alignment and the same sequence of recipes, which I found good):
xLSxPE 9026
LSPExx 9073
LSxxPE 9105
LxxSPE 9133
xxLSPE 9200
LxSPxE 9260
The last one is the best I think, so I've played with it some more time, and now I have 9293 points. If you can to proof any other alignment variant is better, post it here, please.
Happy folding.