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263: Alignment Freestyle

Closed since about 16 years ago

Intermediate

Summary

Created
February 23, 2010
Expires
Max points
100
Description

This is the first sequence alignment puzzle! You can choose "Show Alignment" from the Actions tab to use the new sequence alignment tool. See if you can find a better alignment than the starting one for this structure!

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 9,507
  2. Avatar for Contenders 2. Contenders 76 pts. 9,507
  3. Avatar for Richard Dawkins Foundation 3. Richard Dawkins Foundation 56 pts. 9,503
  4. Avatar for Deleted group 4. Deleted group pts. 9,447
  5. Avatar for Crunching Family 5. Crunching Family 29 pts. 9,427
  6. Avatar for Deleted group 6. Deleted group pts. 9,412
  7. Avatar for Russian team 7. Russian team 14 pts. 9,394
  8. Avatar for Natural Abilities 8. Natural Abilities 9 pts. 9,337
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 6 pts. 9,325
  10. Avatar for Deleted group 10. Deleted group pts. 9,309
  1. Avatar for bvb-2010 31. bvb-2010 Lv 1 23 pts. 9,180
  2. Avatar for marie_s 32. marie_s Lv 1 22 pts. 9,155
  3. Avatar for ETC929 33. ETC929 Lv 1 21 pts. 9,131
  4. Avatar for Susanne 34. Susanne Lv 1 20 pts. 9,129
  5. Avatar for aendgraend 35. aendgraend Lv 1 18 pts. 9,127
  6. Avatar for tedeum 36. tedeum Lv 1 17 pts. 9,125
  7. Avatar for gdnskye 37. gdnskye Lv 1 16 pts. 9,102
  8. Avatar for Wes Borre 38. Wes Borre Lv 1 15 pts. 9,055
  9. Avatar for BootsMcGraw 39. BootsMcGraw Lv 1 15 pts. 9,054
  10. Avatar for JPP 40. JPP Lv 1 14 pts. 9,019

Comments

lilovip Lv 1

Let's look what alignment variants we actually have at this puzzle. It's easy to see there is only one place where we can play with alignment sequence: at the place of 2-aa size space. Changing at any other places will cause huge alignment points reduce. Known protein has the following aa sequence at that place:
SDSQND
And our protein has at start:
LSPxxE
So, now we can place two spaces within this six positions as we wish: they all will give 121 alignment points. I've tryed almost all of the variants. There is table of points for some of them (after alignment and the same sequence of recipes, which I found good):
xLSxPE 9026
LSPExx 9073
LSxxPE 9105
LxxSPE 9133
xxLSPE 9200
LxSPxE 9260
The last one is the best I think, so I've played with it some more time, and now I have 9293 points. If you can to proof any other alignment variant is better, post it here, please.
Happy folding.