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286: Mini-CASP 20 - Better Alignments?

Closed since almost 16 years ago

Intermediate

Summary

Created
April 14, 2010
Expires
Max points
100
Description

Here are 10 different top scoring solutions from 'puzzle 286: Mini-CASP 20 - Better Alignments?'. Try to improve all 10 of them, the solution list will be repopulated often. Read the new blogpost for more info about All Hands.

Top groups

  1. Avatar for ExPitneyFolders 11. ExPitneyFolders 3 pts. 10,190
  2. Avatar for Crunching Family 12. Crunching Family 2 pts. 10,039
  3. Avatar for Natural Abilities 13. Natural Abilities 1 pt. 10,000
  4. Avatar for Deleted group 14. Deleted group pts. 9,713
  5. Avatar for sfb579 15. sfb579 1 pt. 9,418
  6. Avatar for Mac Users 16. Mac Users 1 pt. 9,041
  7. Avatar for Army of One 17. Army of One 1 pt. 8,506
  8. Avatar for DSN @ Home 18. DSN @ Home 1 pt. 7,949
  9. Avatar for Team New Zealand 19. Team New Zealand 1 pt. 7,900
  10. Avatar for Team China 20. Team China 1 pt. 7,656
  1. Avatar for Merf 61. Merf Lv 1 5 pts. 9,555
  2. Avatar for Ozmandias 62. Ozmandias Lv 1 4 pts. 9,480
  3. Avatar for foldzapr 63. foldzapr Lv 1 4 pts. 9,464
  4. Avatar for SouperGenious 64. SouperGenious Lv 1 4 pts. 9,444
  5. Avatar for deep thought 65. deep thought Lv 1 4 pts. 9,418
  6. Avatar for djag 66. djag Lv 1 3 pts. 9,412
  7. Avatar for Squirrely 67. Squirrely Lv 1 3 pts. 9,399
  8. Avatar for chh9513136 68. chh9513136 Lv 1 3 pts. 9,396
  9. Avatar for kaworld3 69. kaworld3 Lv 1 3 pts. 9,351
  10. Avatar for Xyaneon 70. Xyaneon Lv 1 3 pts. 9,349

Comments

beta_helix Staff Lv 1

Many of you noticed (http://fold.it/portal/node/987562) that in puzzle '283: Mini-CASP 20 - Alignments' there were stretched bonds after threading.

Normally, when you thread and a gap needs to be resolved, Foldit fixes this by shrinking the loop.

The problem in this case was that the solved structures for these templates actually had these stretched bonds!!!

Attached is a screenshot of one of the templates: 1n8z (http://www.rcsb.org/pdb/explore/images.do?structureId=1N8Z).


The gap in yellow at the top is in the solved structure. You would think that this is just missing density (that there are a few residues in between there that were disordered or couldn't be solved) but no: that gap is from Leucine 101 to Serine 102.

Sadly, there is nothing we can do about this sort of thing (other than give you what are hopefully better templates) and it might be the case during CASP 9 that the 'best' templates have these kinds of problems!