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286: Mini-CASP 20 - Better Alignments?

Closed since almost 16 years ago

Intermediate

Summary

Created
April 14, 2010
Expires
Max points
100
Description

Here are 10 different top scoring solutions from 'puzzle 286: Mini-CASP 20 - Better Alignments?'. Try to improve all 10 of them, the solution list will be repopulated often. Read the new blogpost for more info about All Hands.

Top groups

  1. Avatar for ExPitneyFolders 11. ExPitneyFolders 3 pts. 10,190
  2. Avatar for Crunching Family 12. Crunching Family 2 pts. 10,039
  3. Avatar for Natural Abilities 13. Natural Abilities 1 pt. 10,000
  4. Avatar for Deleted group 14. Deleted group pts. 9,713
  5. Avatar for sfb579 15. sfb579 1 pt. 9,418
  6. Avatar for Mac Users 16. Mac Users 1 pt. 9,041
  7. Avatar for Army of One 17. Army of One 1 pt. 8,506
  8. Avatar for DSN @ Home 18. DSN @ Home 1 pt. 7,949
  9. Avatar for Team New Zealand 19. Team New Zealand 1 pt. 7,900
  10. Avatar for Team China 20. Team China 1 pt. 7,656
  1. Avatar for Fr0sty 71. Fr0sty Lv 1 2 pts. 9,314
  2. Avatar for tedeum 72. tedeum Lv 1 2 pts. 9,310
  3. Avatar for kleinesregenbogengesicht 73. kleinesregenbogengesicht Lv 1 2 pts. 9,276
  4. Avatar for Ungoliant 74. Ungoliant Lv 1 2 pts. 9,190
  5. Avatar for sbea3 75. sbea3 Lv 1 2 pts. 9,168
  6. Avatar for leprechaun 76. leprechaun Lv 1 2 pts. 9,168
  7. Avatar for rdtsc 77. rdtsc Lv 1 2 pts. 9,162
  8. Avatar for chansuke 78. chansuke Lv 1 2 pts. 9,148
  9. Avatar for yoyo washington 79. yoyo washington Lv 1 1 pt. 9,142
  10. Avatar for Arne Heessels 80. Arne Heessels Lv 1 1 pt. 9,113

Comments

beta_helix Staff Lv 1

Many of you noticed (http://fold.it/portal/node/987562) that in puzzle '283: Mini-CASP 20 - Alignments' there were stretched bonds after threading.

Normally, when you thread and a gap needs to be resolved, Foldit fixes this by shrinking the loop.

The problem in this case was that the solved structures for these templates actually had these stretched bonds!!!

Attached is a screenshot of one of the templates: 1n8z (http://www.rcsb.org/pdb/explore/images.do?structureId=1N8Z).


The gap in yellow at the top is in the solved structure. You would think that this is just missing density (that there are a few residues in between there that were disordered or couldn't be solved) but no: that gap is from Leucine 101 to Serine 102.

Sadly, there is nothing we can do about this sort of thing (other than give you what are hopefully better templates) and it might be the case during CASP 9 that the 'best' templates have these kinds of problems!