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286: Mini-CASP 20 - Better Alignments?

Closed since almost 16 years ago

Intermediate

Summary

Created
April 14, 2010
Expires
Max points
100
Description

Here are 10 different top scoring solutions from 'puzzle 286: Mini-CASP 20 - Better Alignments?'. Try to improve all 10 of them, the solution list will be repopulated often. Read the new blogpost for more info about All Hands.

Top groups

  1. Avatar for Richard Dawkins Foundation
    1. Richard Dawkins Foundation
    100 pts. 10,939
  2. Avatar for Contenders 2. Contenders 77 pts. 10,928
  3. Avatar for Deleted group 3. Deleted group pts. 10,741
  4. Avatar for Void Crushers 4. Void Crushers 43 pts. 10,715
  5. Avatar for SETI.Germany 5. SETI.Germany 31 pts. 10,409
  6. Avatar for Russian team 6. Russian team 22 pts. 10,405
  7. Avatar for Deleted group 7. Deleted group pts. 10,360
  8. Avatar for Mad Lab 8. Mad Lab 11 pts. 10,313
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 7 pts. 10,208
  10. Avatar for Boinc.be 10. Boinc.be 5 pts. 10,208
  1. Avatar for Lockhart 91. Lockhart Lv 1 1 pt. 8,892
  2. Avatar for stormrobberee 92. stormrobberee Lv 1 1 pt. 8,871
  3. Avatar for Seneca 93. Seneca Lv 1 1 pt. 8,842
  4. Avatar for CoachB 94. CoachB Lv 1 1 pt. 8,803
  5. Avatar for BikeLoup 95. BikeLoup Lv 1 1 pt. 8,793
  6. Avatar for ourtown 96. ourtown Lv 1 1 pt. 8,724
  7. Avatar for digitalmad 97. digitalmad Lv 1 1 pt. 8,647
  8. Avatar for Tac1 98. Tac1 Lv 1 1 pt. 8,607
  9. Avatar for goldfish80 99. goldfish80 Lv 1 1 pt. 8,569
  10. Avatar for AndrewSwitch 100. AndrewSwitch Lv 1 1 pt. 8,506

Comments

beta_helix Staff Lv 1

Many of you noticed (http://fold.it/portal/node/987562) that in puzzle '283: Mini-CASP 20 - Alignments' there were stretched bonds after threading.

Normally, when you thread and a gap needs to be resolved, Foldit fixes this by shrinking the loop.

The problem in this case was that the solved structures for these templates actually had these stretched bonds!!!

Attached is a screenshot of one of the templates: 1n8z (http://www.rcsb.org/pdb/explore/images.do?structureId=1N8Z).


The gap in yellow at the top is in the solved structure. You would think that this is just missing density (that there are a few residues in between there that were disordered or couldn't be solved) but no: that gap is from Leucine 101 to Serine 102.

Sadly, there is nothing we can do about this sort of thing (other than give you what are hopefully better templates) and it might be the case during CASP 9 that the 'best' templates have these kinds of problems!