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288: Mini-CASP 22 - Trimmed Sequence

Closed since almost 16 years ago

Intermediate

Summary

Created
April 21, 2010
Expires
Max points
100
Description

Mini-CASP 22 had only 1 template with no alignments to the first 23 residues. This could mean the N-terminus is disordered, so we have trimmed off the first 13 residues (see puzzle comments for more details). We have also included 2 very distant templates, you can see that their scores are quite bad and the starting alignments won't thread, but maybe they can help somehow.

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Comments

beta_helix Staff Lv 1

As you noticed in puzzle 284: Mini-CASP 22 - Single Template, the first 23 residues did not align to the template in the starting alignments.
So we ran this sequence through the Disorder Prediction Servers (using metaPrDOS: protein disorder meta-prediciton server) and here are the results:

You can see that all but one of the disorder prediction servers believe that the N-terminus is indeed disordered, so this is why we have trimmed the first 13 residues.