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358 (<150): TNT Binding: Explosives made fun!

Closed since over 15 years ago

Intermediate Intermediate

Summary

Created
September 01, 2010
Expires
Max points
100
Description

We've got another TNT binding puzzle for you guys! This time it's in a periplasmic binding protein. These proteins are very interesting due to their use in signal transduction systems and because they're fairly dynamic. You'll notice that the protein has a "hinge" in the middle of it (you can imagine the middle of the protein opening up like pac man). This region actually bends back and forth, opening up the binding site and closing it. The goal here is to design the closed protein state such that the TNT ligand will "bridge the gap" and cause the protein to snap shut. The hints mentioned in the previous TNT puzzle still apply and will be repeated in the comments section. For players with fewer than 150 global points.

Top groups

  1. Avatar for Russia 11. Russia 1 pt. 9,534
  2. Avatar for Team China 12. Team China 1 pt. 9,526
  3. Avatar for xkcd 13. xkcd 1 pt. 9,515
  4. Avatar for Void Crushers 14. Void Crushers 1 pt. 9,396
  5. Avatar for L'Alliance Francophone 15. L'Alliance Francophone 1 pt. 9,348
  1. Avatar for Carrawaggio 121. Carrawaggio Lv 1 1 pt. 9,013
  2. Avatar for phil.b 122. phil.b Lv 1 1 pt. 9,013
  3. Avatar for theshortone 123. theshortone Lv 1 1 pt. 9,013
  4. Avatar for snovvfall 124. snovvfall Lv 1 1 pt. 9,013
  5. Avatar for basker11 125. basker11 Lv 1 1 pt. 9,013
  6. Avatar for Cytochrome.X 126. Cytochrome.X Lv 1 1 pt. 9,013
  7. Avatar for almuter 127. almuter Lv 1 1 pt. 9,013
  8. Avatar for SeaEagle 128. SeaEagle Lv 1 1 pt. 9,013
  9. Avatar for 4rm4g3dd0n 129. 4rm4g3dd0n Lv 1 1 pt. 9,013
  10. Avatar for tiimmyy1 130. tiimmyy1 Lv 1 1 pt. 9,013

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