Placeholder image of a protein
Icon representing a puzzle

358 (<150): TNT Binding: Explosives made fun!

Closed since over 15 years ago

Intermediate

Summary

Created
September 01, 2010
Expires
Max points
100
Description

We've got another TNT binding puzzle for you guys! This time it's in a periplasmic binding protein. These proteins are very interesting due to their use in signal transduction systems and because they're fairly dynamic. You'll notice that the protein has a "hinge" in the middle of it (you can imagine the middle of the protein opening up like pac man). This region actually bends back and forth, opening up the binding site and closing it. The goal here is to design the closed protein state such that the TNT ligand will "bridge the gap" and cause the protein to snap shut. The hints mentioned in the previous TNT puzzle still apply and will be repeated in the comments section. For players with fewer than 150 global points.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 9,703
  2. Avatar for Deleted group 2. Deleted group pts. 9,703
  3. Avatar for Russian team 3. Russian team 47 pts. 9,696
  4. Avatar for Crunching Family 4. Crunching Family 30 pts. 9,690
  5. Avatar for SETI.Germany 5. SETI.Germany 19 pts. 9,677
  6. Avatar for Czech National Team 6. Czech National Team 11 pts. 9,666
  7. Avatar for Extraterrestrials 7. Extraterrestrials 7 pts. 9,651
  8. Avatar for DSN @ Home 8. DSN @ Home 4 pts. 9,623
  9. Avatar for Deleted group 9. Deleted group pts. 9,599
  10. Avatar for Habrahabr 10. Habrahabr 1 pt. 9,538
  1. Avatar for simonstpauli 51. simonstpauli Lv 1 10 pts. 9,608
  2. Avatar for Corny 52. Corny Lv 1 9 pts. 9,604
  3. Avatar for Ahiri 3 53. Ahiri 3 Lv 1 9 pts. 9,599
  4. Avatar for Erako 54. Erako Lv 1 8 pts. 9,597
  5. Avatar for CoachB 55. CoachB Lv 1 8 pts. 9,590
  6. Avatar for LordSqueak 56. LordSqueak Lv 1 7 pts. 9,588
  7. Avatar for OmySpy 57. OmySpy Lv 1 7 pts. 9,583
  8. Avatar for kissagram 58. kissagram Lv 1 6 pts. 9,581
  9. Avatar for Merlin3003 59. Merlin3003 Lv 1 6 pts. 9,578
  10. Avatar for Yorcht 60. Yorcht Lv 1 6 pts. 9,577

Comments