Placeholder image of a protein
Icon representing a puzzle

359: Design the Pocket 1

Closed since over 15 years ago

Beginner

Summary

Created
September 10, 2010
Expires
Max points
100
Description

The sidechains closest to the ligand in this puzzle are designable and we need you to find the best possible match! If you are new to Foldit, make sure you have completed the Introductory Design Puzzles (6-1 through 7-2).

Top groups

  1. Avatar for Mmm Helix Fries. 21. Mmm Helix Fries. 1 pt. 13,435
  2. Avatar for Ukraine 22. Ukraine 1 pt. 13,434
  3. Avatar for Super Happy Fun Time 23. Super Happy Fun Time 1 pt. 13,343
  4. Avatar for test_group1 24. test_group1 1 pt. 13,090
  5. Avatar for DSN @ Home 25. DSN @ Home 1 pt. 13,090
  6. Avatar for Extraterrestrials 26. Extraterrestrials 1 pt. 13,090
  7. Avatar for Deleted group 27. Deleted group pts. 13,090
  1. Avatar for Misiek96 261. Misiek96 Lv 1 1 pt. 13,100
  2. Avatar for jjiao1 262. jjiao1 Lv 1 1 pt. 13,100
  3. Avatar for spy club 263. spy club Lv 1 1 pt. 13,100
  4. Avatar for goobea 264. goobea Lv 1 1 pt. 13,094
  5. Avatar for mpark32 265. mpark32 Lv 1 1 pt. 13,090
  6. Avatar for aspadistra 266. aspadistra Lv 1 1 pt. 13,090
  7. Avatar for digitalmad 267. digitalmad Lv 1 1 pt. 13,090
  8. Avatar for redrover 268. redrover Lv 1 1 pt. 13,090
  9. Avatar for Deleted player 269. Deleted player pts. 13,090
  10. Avatar for was_fired 270. was_fired Lv 1 1 pt. 13,090

Comments

Fluttershye Lv 1

Is it intentional that the ligand is locked in place?

I'm a new player, but in the previous design puzzle it was possible to wiggle or manually pull the ligand into an optimal location. Right now, it still seems to be possible to wiggle it around but at a drastically reduced rate (.001 per second about, for as long as you care to let it run).

The result is that I've done about 15 seconds of design, and a few hours of letting it wiggle as it is the only way to move things.

beta_helix Staff Lv 1

If you go into design mode and click on individual designable residues, you can mutate them manually.

This is where we need your help, because our computers can run "Mutate Sidechains" for hours and just get stuck. We are hoping that you can find interactions that "Mutate Sidechains" is unable to detect!