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359: Design the Pocket 1

Closed since over 15 years ago

Beginner

Summary

Created
September 10, 2010
Expires
Max points
100
Description

The sidechains closest to the ligand in this puzzle are designable and we need you to find the best possible match! If you are new to Foldit, make sure you have completed the Introductory Design Puzzles (6-1 through 7-2).

Top groups

  1. Avatar for Mmm Helix Fries. 21. Mmm Helix Fries. 1 pt. 13,435
  2. Avatar for Ukraine 22. Ukraine 1 pt. 13,434
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  4. Avatar for test_group1 24. test_group1 1 pt. 13,090
  5. Avatar for DSN @ Home 25. DSN @ Home 1 pt. 13,090
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  1. Avatar for auntdeen 51. auntdeen Lv 1 49 pts. 13,483
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  7. Avatar for Judecca 57. Judecca Lv 1 45 pts. 13,482
  8. Avatar for kbob 58. kbob Lv 1 44 pts. 13,482
  9. Avatar for metaller 59. metaller Lv 1 43 pts. 13,482
  10. Avatar for yoyo washington 60. yoyo washington Lv 1 43 pts. 13,482

Comments

Fluttershye Lv 1

Is it intentional that the ligand is locked in place?

I'm a new player, but in the previous design puzzle it was possible to wiggle or manually pull the ligand into an optimal location. Right now, it still seems to be possible to wiggle it around but at a drastically reduced rate (.001 per second about, for as long as you care to let it run).

The result is that I've done about 15 seconds of design, and a few hours of letting it wiggle as it is the only way to move things.

beta_helix Staff Lv 1

If you go into design mode and click on individual designable residues, you can mutate them manually.

This is where we need your help, because our computers can run "Mutate Sidechains" for hours and just get stuck. We are hoping that you can find interactions that "Mutate Sidechains" is unable to detect!