Closed since over 15 years ago
BeginnerThe sidechains closest to the ligand in this puzzle are designable and we need you to find the best possible match! If you are new to Foldit, make sure you have completed the Introductory Design Puzzles (6-1 through 7-2).
Is it intentional that the ligand is locked in place?
I'm a new player, but in the previous design puzzle it was possible to wiggle or manually pull the ligand into an optimal location. Right now, it still seems to be possible to wiggle it around but at a drastically reduced rate (.001 per second about, for as long as you care to let it run).
The result is that I've done about 15 seconds of design, and a few hours of letting it wiggle as it is the only way to move things.
Unlike the previous design puzzles, we just want you to search for the sidechains that interact best with the ligand in this particular position.
I am sorry if that was unclear!
What's the ligand?
ligand is that "thing" in the middle of protein
more here : http://en.wikipedia.org/wiki/Ligand :P
Any suggestions on what to do once Mutate side chains and Wiggle do not give any effect?
If you go into design mode and click on individual designable residues, you can mutate them manually.
This is where we need your help, because our computers can run "Mutate Sidechains" for hours and just get stuck. We are hoping that you can find interactions that "Mutate Sidechains" is unable to detect!
