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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

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  4. Avatar for Deleted group 14. Deleted group pts. 14,082
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  6. Avatar for Penny-Arcade 16. Penny-Arcade 1 pt. 14,070
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  8. Avatar for Mmm Helix Fries. 18. Mmm Helix Fries. 1 pt. 14,059
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 14,054
  10. Avatar for xkcd 20. xkcd 1 pt. 14,037
  1. Avatar for Uninformed Opinion 141. Uninformed Opinion Lv 1 4 pts. 14,063
  2. Avatar for Felinho 142. Felinho Lv 1 4 pts. 14,063
  3. Avatar for Deleted player 143. Deleted player pts. 14,062
  4. Avatar for meddy2065 144. meddy2065 Lv 1 4 pts. 14,062
  5. Avatar for smith92clone 145. smith92clone Lv 1 4 pts. 14,062
  6. Avatar for Deleted player 146. Deleted player 4 pts. 14,062
  7. Avatar for AndreasBM 147. AndreasBM Lv 1 4 pts. 14,061
  8. Avatar for MoD 148. MoD Lv 1 3 pts. 14,061
  9. Avatar for gairech 149. gairech Lv 1 3 pts. 14,061
  10. Avatar for JinniaFlyer450 150. JinniaFlyer450 Lv 1 3 pts. 14,061

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.