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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Go Science 11. Go Science 7 pts. 14,108
  2. Avatar for BOINC@Denmark 12. BOINC@Denmark 5 pts. 14,094
  3. Avatar for OMNABEK 13. OMNABEK 4 pts. 14,087
  4. Avatar for Deleted group 14. Deleted group pts. 14,082
  5. Avatar for Slovak National Team 15. Slovak National Team 2 pts. 14,080
  6. Avatar for Penny-Arcade 16. Penny-Arcade 1 pt. 14,070
  7. Avatar for L'Alliance Francophone 17. L'Alliance Francophone 1 pt. 14,064
  8. Avatar for Mmm Helix Fries. 18. Mmm Helix Fries. 1 pt. 14,059
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 14,054
  10. Avatar for xkcd 20. xkcd 1 pt. 14,037
  1. Avatar for foldzapr 171. foldzapr Lv 1 2 pts. 14,057
  2. Avatar for calhoun 172. calhoun Lv 1 2 pts. 14,057
  3. Avatar for Sigian 173. Sigian Lv 1 2 pts. 14,056
  4. Avatar for Volchik 174. Volchik Lv 1 2 pts. 14,056
  5. Avatar for CaNNon 175. CaNNon Lv 1 2 pts. 14,055
  6. Avatar for leprechaun 176. leprechaun Lv 1 2 pts. 14,054
  7. Avatar for Protein_Bender 177. Protein_Bender Lv 1 1 pt. 14,052
  8. Avatar for Ladenhorcher 178. Ladenhorcher Lv 1 1 pt. 14,051
  9. Avatar for Kelthoras 179. Kelthoras Lv 1 1 pt. 14,051
  10. Avatar for alexob12 180. alexob12 Lv 1 1 pt. 14,051

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.