Placeholder image of a protein
Icon representing a puzzle

366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Go Science 11. Go Science 7 pts. 14,108
  2. Avatar for BOINC@Denmark 12. BOINC@Denmark 5 pts. 14,094
  3. Avatar for OMNABEK 13. OMNABEK 4 pts. 14,087
  4. Avatar for Deleted group 14. Deleted group pts. 14,082
  5. Avatar for Slovak National Team 15. Slovak National Team 2 pts. 14,080
  6. Avatar for Penny-Arcade 16. Penny-Arcade 1 pt. 14,070
  7. Avatar for L'Alliance Francophone 17. L'Alliance Francophone 1 pt. 14,064
  8. Avatar for Mmm Helix Fries. 18. Mmm Helix Fries. 1 pt. 14,059
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 14,054
  10. Avatar for xkcd 20. xkcd 1 pt. 14,037
  1. Avatar for vakobo 11. vakobo Lv 1 84 pts. 14,213
  2. Avatar for marie_s 12. marie_s Lv 1 83 pts. 14,201
  3. Avatar for justjustin 13. justjustin Lv 1 82 pts. 14,199
  4. Avatar for vertex 14. vertex Lv 1 80 pts. 14,199
  5. Avatar for BootsMcGraw 15. BootsMcGraw Lv 1 79 pts. 14,193
  6. Avatar for drjr 16. drjr Lv 1 77 pts. 14,192
  7. Avatar for Dolichwier 17. Dolichwier Lv 1 76 pts. 14,189
  8. Avatar for grabhorn 18. grabhorn Lv 1 75 pts. 14,184
  9. Avatar for katling 19. katling Lv 1 73 pts. 14,184
  10. Avatar for Mr_Jolty 20. Mr_Jolty Lv 1 72 pts. 14,177

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.