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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Go Science 11. Go Science 7 pts. 14,108
  2. Avatar for BOINC@Denmark 12. BOINC@Denmark 5 pts. 14,094
  3. Avatar for OMNABEK 13. OMNABEK 4 pts. 14,087
  4. Avatar for Deleted group 14. Deleted group pts. 14,082
  5. Avatar for Slovak National Team 15. Slovak National Team 2 pts. 14,080
  6. Avatar for Penny-Arcade 16. Penny-Arcade 1 pt. 14,070
  7. Avatar for L'Alliance Francophone 17. L'Alliance Francophone 1 pt. 14,064
  8. Avatar for Mmm Helix Fries. 18. Mmm Helix Fries. 1 pt. 14,059
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 14,054
  10. Avatar for xkcd 20. xkcd 1 pt. 14,037
  1. Avatar for aendgraend 31. aendgraend Lv 1 59 pts. 14,145
  2. Avatar for spmm 32. spmm Lv 1 57 pts. 14,145
  3. Avatar for BuzzDee 33. BuzzDee Lv 1 56 pts. 14,140
  4. Avatar for philcalhoun 34. philcalhoun Lv 1 55 pts. 14,140
  5. Avatar for Rav3n_pl 35. Rav3n_pl Lv 1 54 pts. 14,139
  6. Avatar for grastgirl 36. grastgirl Lv 1 53 pts. 14,135
  7. Avatar for Kit Cosby 37. Kit Cosby Lv 1 52 pts. 14,134
  8. Avatar for talon5454 38. talon5454 Lv 1 51 pts. 14,134
  9. Avatar for gdnskye 39. gdnskye Lv 1 50 pts. 14,131
  10. Avatar for weitzen 40. weitzen Lv 1 49 pts. 14,123

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.