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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for foldzapr 171. foldzapr Lv 1 2 pts. 14,057
  2. Avatar for calhoun 172. calhoun Lv 1 2 pts. 14,057
  3. Avatar for Sigian 173. Sigian Lv 1 2 pts. 14,056
  4. Avatar for Volchik 174. Volchik Lv 1 2 pts. 14,056
  5. Avatar for CaNNon 175. CaNNon Lv 1 2 pts. 14,055
  6. Avatar for leprechaun 176. leprechaun Lv 1 2 pts. 14,054
  7. Avatar for Protein_Bender 177. Protein_Bender Lv 1 1 pt. 14,052
  8. Avatar for Ladenhorcher 178. Ladenhorcher Lv 1 1 pt. 14,051
  9. Avatar for Kelthoras 179. Kelthoras Lv 1 1 pt. 14,051
  10. Avatar for alexob12 180. alexob12 Lv 1 1 pt. 14,051

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.