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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for Jim Fraser 181. Jim Fraser Lv 1 1 pt. 14,050
  2. Avatar for jobo0502 182. jobo0502 Lv 1 1 pt. 14,049
  3. Avatar for cayleschertz 183. cayleschertz Lv 1 1 pt. 14,047
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  5. Avatar for tolkienrocks 185. tolkienrocks Lv 1 1 pt. 14,047
  6. Avatar for doraion 186. doraion Lv 1 1 pt. 14,047
  7. Avatar for Sergey2002 187. Sergey2002 Lv 1 1 pt. 14,046
  8. Avatar for benjyl 188. benjyl Lv 1 1 pt. 14,046
  9. Avatar for Pyrohmstr 189. Pyrohmstr Lv 1 1 pt. 14,046
  10. Avatar for DimitriM 190. DimitriM Lv 1 1 pt. 14,046

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.