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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for tim1079 211. tim1079 Lv 1 1 pt. 14,040
  2. Avatar for 12jesset 212. 12jesset Lv 1 1 pt. 14,040
  3. Avatar for soviet_bear_82 213. soviet_bear_82 Lv 1 1 pt. 14,040
  4. Avatar for Fluttershye 214. Fluttershye Lv 1 1 pt. 14,039
  5. Avatar for seeker 215. seeker Lv 1 1 pt. 14,038
  6. Avatar for sd3000 216. sd3000 Lv 1 1 pt. 14,038
  7. Avatar for Seneca 217. Seneca Lv 1 1 pt. 14,038
  8. Avatar for gintaras46 218. gintaras46 Lv 1 1 pt. 14,038
  9. Avatar for Ysabell 219. Ysabell Lv 1 1 pt. 14,038
  10. Avatar for vinceis1337 220. vinceis1337 Lv 1 1 pt. 14,037

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.