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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for cashome 221. cashome Lv 1 1 pt. 14,037
  2. Avatar for pandeer 222. pandeer Lv 1 1 pt. 14,037
  3. Avatar for Joshua.Weitzman 223. Joshua.Weitzman Lv 1 1 pt. 14,037
  4. Avatar for Fred Erik 224. Fred Erik Lv 1 1 pt. 14,036
  5. Avatar for Dantes 225. Dantes Lv 1 1 pt. 14,036
  6. Avatar for Avec 226. Avec Lv 1 1 pt. 14,036
  7. Avatar for tuxedocat 227. tuxedocat Lv 1 1 pt. 14,035
  8. Avatar for Sir Link 228. Sir Link Lv 1 1 pt. 14,030
  9. Avatar for jed82 229. jed82 Lv 1 1 pt. 14,027
  10. Avatar for hash777 230. hash777 Lv 1 1 pt. 14,023

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.