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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for aendgraend 31. aendgraend Lv 1 59 pts. 14,145
  2. Avatar for spmm 32. spmm Lv 1 57 pts. 14,145
  3. Avatar for BuzzDee 33. BuzzDee Lv 1 56 pts. 14,140
  4. Avatar for philcalhoun 34. philcalhoun Lv 1 55 pts. 14,140
  5. Avatar for Rav3n_pl 35. Rav3n_pl Lv 1 54 pts. 14,139
  6. Avatar for grastgirl 36. grastgirl Lv 1 53 pts. 14,135
  7. Avatar for Kit Cosby 37. Kit Cosby Lv 1 52 pts. 14,134
  8. Avatar for talon5454 38. talon5454 Lv 1 51 pts. 14,134
  9. Avatar for gdnskye 39. gdnskye Lv 1 50 pts. 14,131
  10. Avatar for weitzen 40. weitzen Lv 1 49 pts. 14,123

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.