Placeholder image of a protein
Icon representing a puzzle

366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for anthunk 41. anthunk Lv 1 48 pts. 14,115
  2. Avatar for Judecca 42. Judecca Lv 1 47 pts. 14,115
  3. Avatar for Merf 43. Merf Lv 1 46 pts. 14,114
  4. Avatar for Tlaloc 44. Tlaloc Lv 1 45 pts. 14,110
  5. Avatar for Karamazov 45. Karamazov Lv 1 45 pts. 14,109
  6. Avatar for caervius 46. caervius Lv 1 44 pts. 14,108
  7. Avatar for MSCthulhu 47. MSCthulhu Lv 1 43 pts. 14,104
  8. Avatar for anne romaine 48. anne romaine Lv 1 42 pts. 14,101
  9. Avatar for Khaoz 49. Khaoz Lv 1 41 pts. 14,099
  10. Avatar for pyropuppets 50. pyropuppets Lv 1 40 pts. 14,099

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.