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366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 14,005
  2. Avatar for Canadian Universities 22. Canadian Universities 1 pt. 14,003
  3. Avatar for Team China 23. Team China 1 pt. 13,987
  4. Avatar for Rice Biochemistry 24. Rice Biochemistry 1 pt. 13,987
  5. Avatar for Deleted group 25. Deleted group pts. 13,977
  1. Avatar for Jedrik 51. Jedrik Lv 1 39 pts. 14,096
  2. Avatar for Grom 52. Grom Lv 1 39 pts. 14,095
  3. Avatar for thosi 53. thosi Lv 1 38 pts. 14,094
  4. Avatar for sbea3 54. sbea3 Lv 1 37 pts. 14,091
  5. Avatar for MooMooMan 55. MooMooMan Lv 1 36 pts. 14,091
  6. Avatar for poictesme 56. poictesme Lv 1 36 pts. 14,090
  7. Avatar for Ignacio 57. Ignacio Lv 1 35 pts. 14,089
  8. Avatar for kbob 58. kbob Lv 1 34 pts. 14,089
  9. Avatar for Savas 59. Savas Lv 1 33 pts. 14,088
  10. Avatar for SIW 60. SIW Lv 1 33 pts. 14,088

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.