Placeholder image of a protein
Icon representing a puzzle

366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 14,280
  2. Avatar for Void Crushers 2. Void Crushers 81 pts. 14,276
  3. Avatar for Russian team 3. Russian team 65 pts. 14,253
  4. Avatar for Richard Dawkins Foundation 4. Richard Dawkins Foundation 52 pts. 14,232
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 41 pts. 14,225
  6. Avatar for Deleted group 6. Deleted group pts. 14,199
  7. Avatar for Natural Abilities 7. Natural Abilities 24 pts. 14,177
  8. Avatar for SETI.Germany 8. SETI.Germany 18 pts. 14,145
  9. Avatar for Deleted group 9. Deleted group pts. 14,140
  10. Avatar for Mojo Risin' 10. Mojo Risin' 10 pts. 14,110
  1. Avatar for infjamc 11. infjamc Lv 1 10 pts. 14,247
  2. Avatar for Bletchley Park 12. Bletchley Park Lv 1 8 pts. 14,245
  3. Avatar for anthunk 13. anthunk Lv 1 6 pts. 14,225
  4. Avatar for anthion 14. anthion Lv 1 4 pts. 14,225
  5. Avatar for vakobo 15. vakobo Lv 1 3 pts. 14,221
  6. Avatar for Khaoz 16. Khaoz Lv 1 2 pts. 14,207
  7. Avatar for dimension9 17. dimension9 Lv 1 2 pts. 14,207
  8. Avatar for bareego 18. bareego Lv 1 1 pt. 14,207
  9. Avatar for itskimo 19. itskimo Lv 1 1 pt. 14,207
  10. Avatar for auntdeen 20. auntdeen Lv 1 1 pt. 14,200

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.