Beginner Puzzle: Headpiece Domain of Chicken Villin

Closed since about 15 years ago

Summary

• Created: February 14, 2011
• Expires: March 17, 2011 at 23:00 UTC
• Max points: 100

Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide?

Top groups

• 21. CHS SGF,MO 2 pts. 9,412
• 22. Extraterrestrials 2 pts. 9,387
• 23. Nerdfighters 1 pt. 9,368
• 24. Crunching Family 1 pt. 9,348
• 25. Czech National Team 1 pt. 9,289
• 26. Deleted group pts. 9,264
• 27. Planet IX 1 pt. 9,182
• 28. Team Canada 1 pt. 9,178
• 29. Mojo Risin' 1 pt. 9,170
• 30. Boinc.be 1 pt. 9,083

Top soloists

• 41. phi16 72 pts. 9,569
• 42. caglar 72 pts. 9,567
• 43. auntdeen 71 pts. 9,566
• 44. Ch Garnier 71 pts. 9,565
• 45. djag 70 pts. 9,561
• 46. Mitchincredible 69 pts. 9,561
• 47. katling 69 pts. 9,561
• 48. HillObserver 68 pts. 9,560
• 49. foley8 68 pts. 9,558
• 50. anthunk 67 pts. 9,556

Comments

[beta_helix]

If this is your first time playing Foldit, here are instructions for you to get started:

http://fold.it/portal/node/988864

[Rav3n_pl]

comment about that protein?
Found nice wiki article:

en.wikipedia.org

Villin-1

Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. Villin-1 is encoded by the VIL1 gene. Villin-1 contains multiple gelsolin-like domains capped by a small (8.5 kDa) "headpiece" at the C-terminus consisting of a fast and independently folding three-helix bundle that is stabilized by hydrophobic interactions. The headpiece domain is a commonly studied protein in molecular dynamics due to its small size and fast folding kine Villi...

[LorraineMae]

when I shake the sidechains? Why? Playing Headpiece Domain of Chicken Villin.

[LorraineMae]

I am wiggling backbone. Why so many abends–about five so far.