Beginner Puzzle: Headpiece Domain of Chicken Villin

Closed since about 15 years ago

Summary

• Created: February 14, 2011
• Expires: March 17, 2011 at 23:00 UTC
• Max points: 100

Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide?

Top groups

• 31. Hungary 1 pt. 9,058
• 32. Deleted group pts. 9,022
• 33. Penny-Arcade 1 pt. 8,898
• 34. DSN @ Home 1 pt. 8,843
• 35. Biomedsci 1 pt. 8,834
• 36. Deleted group pts. 8,667

Top soloists

• 411. fo40225 1 pt. 8,970
• 412. SpreijStudios 1 pt. 8,969
• 413. fabianhjr 1 pt. 8,967
• 414. cspirou 1 pt. 8,967
• 415. Zspencer123 1 pt. 8,966
• 416. chem4523-Michaud 1 pt. 8,965
• 417. Sgt Bisendi 1 pt. 8,963
• 418. chem4523-daigle 1 pt. 8,962
• 419. chem4523-Nugent 1 pt. 8,961
• 420. caro_mi 1 pt. 8,957

Comments

[beta_helix]

If this is your first time playing Foldit, here are instructions for you to get started:

http://fold.it/portal/node/988864

[Rav3n_pl]

comment about that protein?
Found nice wiki article:

en.wikipedia.org

Villin-1

Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. Villin-1 is encoded by the VIL1 gene. Villin-1 contains multiple gelsolin-like domains capped by a small (8.5 kDa) "headpiece" at the C-terminus consisting of a fast and independently folding three-helix bundle that is stabilized by hydrophobic interactions. The headpiece domain is a commonly studied protein in molecular dynamics due to its small size and fast folding kine Villi...

[LorraineMae]

when I shake the sidechains? Why? Playing Headpiece Domain of Chicken Villin.

[LorraineMae]

I am wiggling backbone. Why so many abends–about five so far.