Beginner Puzzle: Headpiece Domain of Chicken Villin

Closed since almost 15 years ago

Summary

• Created: February 14, 2011
• Expires: March 17, 2011 at 23:00 UTC
• Max points: 100

Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide?

Top groups

• 1. Anthropic Dreams 100 pts. 9,712
• 2. Go Science 87 pts. 9,708
• 3. Contenders 75 pts. 9,663
• 4. Deleted group pts. 9,655
• 5. xkcd 55 pts. 9,653
• 6. foldeRNA 47 pts. 9,646
• 7. Void Crushers 40 pts. 9,638
• 8. Deleted group pts. 9,629
• 9. L'Alliance Francophone 28 pts. 9,624
• 10. Russian team 23 pts. 9,623

Top evolvers

• 11. itskimo 22 pts. 9,694
• 12. Deleted player pts. 9,686
• 13. Deleted player pts. 9,678
• 14. itsmsjeans 13 pts. 9,676
• 15. QueenJ 11 pts. 9,676
• 16. BrightSun 9 pts. 9,676
• 17. Hanto_FZ140E_4G 7 pts. 9,675
• 18. DC1600 6 pts. 9,674
• 19. pauldunn 5 pts. 9,673
• 20. B_2 4 pts. 9,672

Comments

[beta_helix]

If this is your first time playing Foldit, here are instructions for you to get started:

http://fold.it/portal/node/988864

[Rav3n_pl]

comment about that protein?
Found nice wiki article:

en.wikipedia.org

Villin-1

Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. Villin-1 is encoded by the VIL1 gene. Villin-1 contains multiple gelsolin-like domains capped by a small (8.5 kDa) "headpiece" at the C-terminus consisting of a fast and independently folding three-helix bundle that is stabilized by hydrophobic interactions. The headpiece domain is a commonly studied protein in molecular dynamics due to its small size and fast folding kine Villi...

[LorraineMae]

when I shake the sidechains? Why? Playing Headpiece Domain of Chicken Villin.

[LorraineMae]

I am wiggling backbone. Why so many abends–about five so far.