Placeholder image of a protein
Icon representing a puzzle

400: De-novo Freestyle 4

Closed since about 15 years ago

Advanced Overall Prediction

Summary

Created
February 15, 2011
Expires
Max points
100
Description

Our 400th puzzle is another currently unsolved protein that we are giving to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, you'll notice this sequence is similar to Puzzle 398: De-novo Freestyle 3. THIS PUZZLE HAS BEEN EXTENDED BY 1 DAY!

Top groups

  1. Avatar for Nerdfighters 21. Nerdfighters 1 pt. 10,244
  2. Avatar for Crunching Family 22. Crunching Family 1 pt. 10,063
  3. Avatar for Russian team 23. Russian team 1 pt. 9,976
  4. Avatar for Deleted group 24. Deleted group pts. 9,937
  5. Avatar for Team Commonwealth 25. Team Commonwealth 1 pt. 9,902
  6. Avatar for Dutch Power Cows 26. Dutch Power Cows 1 pt. 8,673
  7. Avatar for Czech National Team 27. Czech National Team 1 pt. 8,380
  8. Avatar for Extraterrestrials 28. Extraterrestrials 1 pt. 7,705
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 7,654
  10. Avatar for Biotech at Collin 30. Biotech at Collin 1 pt. 2,401
  1. Avatar for pamdemonia 291. pamdemonia Lv 1 1 pt. 7,700
  2. Avatar for Eedray 292. Eedray Lv 1 1 pt. 7,699
  3. Avatar for reginald_herring 293. reginald_herring Lv 1 1 pt. 7,699
  4. Avatar for mimckinl 294. mimckinl Lv 1 1 pt. 7,699
  5. Avatar for GonadsAndStrife 295. GonadsAndStrife Lv 1 1 pt. 7,699
  6. Avatar for Alex-Victor 296. Alex-Victor Lv 1 1 pt. 7,699
  7. Avatar for uwe zwidtmeyr 297. uwe zwidtmeyr Lv 1 1 pt. 7,699
  8. Avatar for rockntroll1200 298. rockntroll1200 Lv 1 1 pt. 7,697
  9. Avatar for poko610 299. poko610 Lv 1 1 pt. 7,696
  10. Avatar for gratogog 300. gratogog Lv 1 1 pt. 7,696

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 26 is highly predicted to be part of a helix. However, the Leucine at residue 34 is predicted to have an equal probability of being anything.

Deleted user

The protein is Bile acid 7a-dehydratase

It belongs to the bacteria organism Eubacterium sp.

Catalyzes the dehydratation of 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate. The enzyme can also use 7-alpha-hydroxy-3-oxochol-4-enoate as a substrate but not 7-alpha,12-alpha-dihydroxy-3-oxochol-5-beta-anoate, 3-alpha,7-alpha,12-alpha-trihydroxychol-5-beta-anoate or 7-beta-hydroxy-3-oxochol-4-enoate

For more info: Go to the uniprot ascession number P19412