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400: De-novo Freestyle 4

Closed since about 15 years ago

Advanced Overall Prediction

Summary

Created
February 15, 2011
Expires
Max points
100
Description

Our 400th puzzle is another currently unsolved protein that we are giving to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, you'll notice this sequence is similar to Puzzle 398: De-novo Freestyle 3. THIS PUZZLE HAS BEEN EXTENDED BY 1 DAY!

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Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 26 is highly predicted to be part of a helix. However, the Leucine at residue 34 is predicted to have an equal probability of being anything.

Deleted user

The protein is Bile acid 7a-dehydratase

It belongs to the bacteria organism Eubacterium sp.

Catalyzes the dehydratation of 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate. The enzyme can also use 7-alpha-hydroxy-3-oxochol-4-enoate as a substrate but not 7-alpha,12-alpha-dihydroxy-3-oxochol-5-beta-anoate, 3-alpha,7-alpha,12-alpha-trihydroxychol-5-beta-anoate or 7-beta-hydroxy-3-oxochol-4-enoate

For more info: Go to the uniprot ascession number P19412