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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for xkcd 11. xkcd 17 pts. 10,009
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  1. Avatar for RyeSnake 251. RyeSnake Lv 1 9 pts. 9,238
  2. Avatar for Ningiizzida 252. Ningiizzida Lv 1 9 pts. 9,237
  3. Avatar for crispy fry 253. crispy fry Lv 1 9 pts. 9,235
  4. Avatar for kinglewi 254. kinglewi Lv 1 9 pts. 9,234
  5. Avatar for cherimole 255. cherimole Lv 1 8 pts. 9,234
  6. Avatar for rinze 256. rinze Lv 1 8 pts. 9,229
  7. Avatar for oxyi 257. oxyi Lv 1 8 pts. 9,226
  8. Avatar for kleiner.elm 258. kleiner.elm Lv 1 8 pts. 9,221
  9. Avatar for amtao 259. amtao Lv 1 8 pts. 9,219
  10. Avatar for awu 260. awu Lv 1 8 pts. 9,214

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).