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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for xkcd 11. xkcd 17 pts. 10,009
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  7. Avatar for Mojo Risin' 17. Mojo Risin' 4 pts. 9,786
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  9. Avatar for hhv9 19. hhv9 2 pts. 9,756
  10. Avatar for Nerdfighters 20. Nerdfighters 2 pts. 9,713
  1. Avatar for tjs38grad 301. tjs38grad Lv 1 5 pts. 9,123
  2. Avatar for SergNL 302. SergNL Lv 1 5 pts. 9,123
  3. Avatar for x_n0na_x 303. x_n0na_x Lv 1 5 pts. 9,117
  4. Avatar for Aristea 304. Aristea Lv 1 5 pts. 9,117
  5. Avatar for bbb 305. bbb Lv 1 4 pts. 9,116
  6. Avatar for Genius55x 306. Genius55x Lv 1 4 pts. 9,111
  7. Avatar for The Oak 307. The Oak Lv 1 4 pts. 9,107
  8. Avatar for Cerzax 308. Cerzax Lv 1 4 pts. 9,107
  9. Avatar for groundbreaking 309. groundbreaking Lv 1 4 pts. 9,106
  10. Avatar for Thallium 310. Thallium Lv 1 4 pts. 9,101

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).