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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for xkcd 11. xkcd 17 pts. 10,009
  2. Avatar for L'Alliance Francophone 12. L'Alliance Francophone 14 pts. 9,993
  3. Avatar for Deleted group 13. Deleted group pts. 9,966
  4. Avatar for Slovak National Team 14. Slovak National Team 9 pts. 9,935
  5. Avatar for SETI.Germany 15. SETI.Germany 7 pts. 9,912
  6. Avatar for Deleted group 16. Deleted group pts. 9,836
  7. Avatar for Mojo Risin' 17. Mojo Risin' 4 pts. 9,786
  8. Avatar for Penny-Arcade 18. Penny-Arcade 3 pts. 9,784
  9. Avatar for hhv9 19. hhv9 2 pts. 9,756
  10. Avatar for Nerdfighters 20. Nerdfighters 2 pts. 9,713
  1. Avatar for caglar 31. caglar Lv 1 79 pts. 10,131
  2. Avatar for ncm25_OLD 32. ncm25_OLD Lv 1 78 pts. 10,114
  3. Avatar for auntdeen 33. auntdeen Lv 1 78 pts. 10,112
  4. Avatar for Sidran 34. Sidran Lv 1 77 pts. 10,104
  5. Avatar for Tony Origami 35. Tony Origami Lv 1 77 pts. 10,096
  6. Avatar for BitSpawn 36. BitSpawn Lv 1 76 pts. 10,084
  7. Avatar for kbob 37. kbob Lv 1 75 pts. 10,082
  8. Avatar for rsosborne 38. rsosborne Lv 1 75 pts. 10,082
  9. Avatar for Jim Fraser 39. Jim Fraser Lv 1 74 pts. 10,057
  10. Avatar for gcm24 40. gcm24 Lv 1 73 pts. 10,036

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).