Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for Ukraine 21. Ukraine 1 pt. 9,679
  2. Avatar for Team Commonwealth 22. Team Commonwealth 1 pt. 9,638
  3. Avatar for TT-group 23. TT-group 1 pt. 9,630
  4. Avatar for Czech National Team 24. Czech National Team 1 pt. 9,605
  5. Avatar for Eὕρηκα! Heureka! 25. Eὕρηκα! Heureka! 1 pt. 9,537
  6. Avatar for Richard Dawkins Foundation 26. Richard Dawkins Foundation 1 pt. 9,467
  7. Avatar for Crunching Family 27. Crunching Family 1 pt. 9,437
  8. Avatar for Extraterrestrials 28. Extraterrestrials 1 pt. 9,272
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 8,926
  10. Avatar for University of Washington 30. University of Washington 1 pt. 8,926
  1. Avatar for CoachB 241. CoachB Lv 1 10 pts. 9,265
  2. Avatar for Mneme 242. Mneme Lv 1 10 pts. 9,264
  3. Avatar for Deleted player 243. Deleted player pts. 9,264
  4. Avatar for barbaranne 244. barbaranne Lv 1 10 pts. 9,263
  5. Avatar for Lord_Rey 245. Lord_Rey Lv 1 10 pts. 9,262
  6. Avatar for jeanjean 246. jeanjean Lv 1 9 pts. 9,252
  7. Avatar for lynnj15 247. lynnj15 Lv 1 9 pts. 9,250
  8. Avatar for TheMarcophone 248. TheMarcophone Lv 1 9 pts. 9,246
  9. Avatar for dglion 249. dglion Lv 1 9 pts. 9,243
  10. Avatar for Glioma 250. Glioma Lv 1 9 pts. 9,241

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).