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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for Goons with proteins 31. Goons with proteins 1 pt. 8,910
  2. Avatar for BOINC@Poland 32. BOINC@Poland 1 pt. 8,845
  3. Avatar for test_group1 33. test_group1 1 pt. 8,845
  4. Avatar for Australia 34. Australia 1 pt. 8,845
  1. Avatar for nix meow 401. nix meow Lv 1 1 pt. 8,931
  2. Avatar for Jaspi10 402. Jaspi10 Lv 1 1 pt. 8,931
  3. Avatar for SEF 403. SEF Lv 1 1 pt. 8,931
  4. Avatar for tsnud 404. tsnud Lv 1 1 pt. 8,931
  5. Avatar for ashar 405. ashar Lv 1 1 pt. 8,930
  6. Avatar for chemistsrule 406. chemistsrule Lv 1 1 pt. 8,930
  7. Avatar for Tangmo 407. Tangmo Lv 1 1 pt. 8,929
  8. Avatar for Dodecahedron314 408. Dodecahedron314 Lv 1 1 pt. 8,929
  9. Avatar for acarm 409. acarm Lv 1 1 pt. 8,928
  10. Avatar for ihar025 410. ihar025 Lv 1 1 pt. 8,928

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).