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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for Goons with proteins 31. Goons with proteins 1 pt. 8,910
  2. Avatar for BOINC@Poland 32. BOINC@Poland 1 pt. 8,845
  3. Avatar for test_group1 33. test_group1 1 pt. 8,845
  4. Avatar for Australia 34. Australia 1 pt. 8,845
  1. Avatar for Alex89 631. Alex89 Lv 1 1 pt. 8,845
  2. Avatar for fep 632. fep Lv 1 1 pt. 8,845
  3. Avatar for Poly 633. Poly Lv 1 1 pt. 8,845
  4. Avatar for jank5 634. jank5 Lv 1 1 pt. 8,845
  5. Avatar for gianmarco 635. gianmarco Lv 1 1 pt. 8,845
  6. Avatar for guyamit531 636. guyamit531 Lv 1 1 pt. 8,845
  7. Avatar for backster 637. backster Lv 1 1 pt. 8,845
  8. Avatar for j11sh15rt 638. j11sh15rt Lv 1 1 pt. 8,845
  9. Avatar for Jason Fishman 639. Jason Fishman Lv 1 1 pt. 8,845
  10. Avatar for romuluswolf 640. romuluswolf Lv 1 1 pt. 8,845

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).