Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle: T-cell Lymphoma Invasion Protein

Closed since almost 15 years ago

Intermediate

Summary

Created
March 20, 2011
Expires
Max points
100
Description

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 10,351
  2. Avatar for Contenders 2. Contenders 86 pts. 10,340
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 74 pts. 10,336
  4. Avatar for foldeRNA 4. foldeRNA 63 pts. 10,288
  5. Avatar for Go Science 5. Go Science 53 pts. 10,254
  6. Avatar for Deleted group 6. Deleted group pts. 10,225
  7. Avatar for Natural Abilities 7. Natural Abilities 37 pts. 10,219
  8. Avatar for Deleted group 8. Deleted group pts. 10,210
  9. Avatar for Russian team 9. Russian team 25 pts. 10,176
  10. Avatar for Pauling's Pitbulls 10. Pauling's Pitbulls 21 pts. 10,132
  1. Avatar for thebluesun 461. thebluesun Lv 1 1 pt. 8,923
  2. Avatar for alphaCentauri 462. alphaCentauri Lv 1 1 pt. 8,923
  3. Avatar for maaikel 463. maaikel Lv 1 1 pt. 8,923
  4. Avatar for shadow1 464. shadow1 Lv 1 1 pt. 8,923
  5. Avatar for gumwrapper 465. gumwrapper Lv 1 1 pt. 8,923
  6. Avatar for jpillai 466. jpillai Lv 1 1 pt. 8,923
  7. Avatar for Roelz 467. Roelz Lv 1 1 pt. 8,923
  8. Avatar for Lightmaxime 468. Lightmaxime Lv 1 1 pt. 8,922
  9. Avatar for Sgt Bisendi 469. Sgt Bisendi Lv 1 1 pt. 8,922
  10. Avatar for spanishvader 470. spanishvader Lv 1 1 pt. 8,922

Comments

beta_helix Staff Lv 1

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).