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412: Electron Density Trace Puzzle

Closed since almost 15 years ago

Intermediate Overall Prediction

Summary

Created
April 16, 2011
Expires
Max points
100
Description

This Rosetta model was generated by trying to fit an electron density map, but as you can see the resulting trace looks pretty bad. We have tried various Rosetta protocols on this model but they aren't able to make it look any better, so we are hoping your human skills can spot what areas need to be improved the most.

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Comments

Rav3n_pl Lv 1

to optimize it or make own folds?
Make totally fifferent aligement or "just" optimize existing one?

Origami314 Lv 1

I looked up Electron Density Trace and I got the impression that the method predicts where each AA probably is with some margin for error. So, does that mean we should try not to change their locations too much? Is there any chance you can show us the original results with the probabilities?

beta_helix Staff Lv 1

Indeed, the data indicates that this model is close to the native geometrically but you can see that it needs a lot of work and optimization.

So drastic restructuring moves should not be necessary, but finding the native low-energy well should still be a challenge!

I will see if we can provide you with some of the experimental data, if not on this puzzle we can try it with future puzzles.