Placeholder image of a protein
Icon representing a puzzle

420: Mini Protein Puzzle 2: Ebola Ligand

Closed since almost 15 years ago

Intermediate Intermediate Overall Overall Prediction Prediction

Summary

Created
May 13, 2011
Expires
Max points
100
Description

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments.

Top groups

  1. Avatar for Slovak National Team 11. Slovak National Team 5 pts. 8,689
  2. Avatar for Purdue BoilerFolders 12. Purdue BoilerFolders 4 pts. 8,676
  3. Avatar for Russian team 13. Russian team 2 pts. 8,644
  4. Avatar for Speedfolders 14. Speedfolders 2 pts. 8,571
  5. Avatar for Eὕρηκα! Heureka! 15. Eὕρηκα! Heureka! 1 pt. 8,563
  6. Avatar for Extraterrestrials 16. Extraterrestrials 1 pt. 8,556
  7. Avatar for Natural Abilities 17. Natural Abilities 1 pt. 8,547
  8. Avatar for Argentina 18. Argentina 1 pt. 8,518
  9. Avatar for Deleted group 19. Deleted group pts. 8,277
  10. Avatar for Crunching Family 20. Crunching Family 1 pt. 8,274
  1. Avatar for justjustin 101. justjustin Lv 1 4 pts. 8,588
  2. Avatar for anne romaine 102. anne romaine Lv 1 4 pts. 8,587
  3. Avatar for Sergey2002 103. Sergey2002 Lv 1 4 pts. 8,584
  4. Avatar for Steve001 104. Steve001 Lv 1 4 pts. 8,583
  5. Avatar for HillObserver 105. HillObserver Lv 1 4 pts. 8,582
  6. Avatar for Fat Tony 106. Fat Tony Lv 1 3 pts. 8,579
  7. Avatar for yoyo washington 107. yoyo washington Lv 1 3 pts. 8,579
  8. Avatar for mirjamvandelft 108. mirjamvandelft Lv 1 3 pts. 8,577
  9. Avatar for kaustic 109. kaustic Lv 1 3 pts. 8,571
  10. Avatar for jwindham 110. jwindham Lv 1 3 pts. 8,571

Comments

beta_helix Staff Lv 1

This tiny domain is an independently-folding piece of a larger ubiquitin ligase protein, responsible for tagging proteins with ubiquitin (also a protein) thereby marking them for death.

This particular ubiquitin ligase is capable of binding and tagging viral proteins - but this turns out to be a bad thing, as certain viruses (like Ebola) need to have ubiquitin attached to one of their proteins in order to break free of the host cell that made them.