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420: Mini Protein Puzzle 2: Ebola Ligand

Closed since almost 15 years ago

Intermediate Overall Prediction

Summary

Created
May 13, 2011
Expires
Max points
100
Description

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments.

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Comments

beta_helix Staff Lv 1

This tiny domain is an independently-folding piece of a larger ubiquitin ligase protein, responsible for tagging proteins with ubiquitin (also a protein) thereby marking them for death.

This particular ubiquitin ligase is capable of binding and tagging viral proteins - but this turns out to be a bad thing, as certain viruses (like Ebola) need to have ubiquitin attached to one of their proteins in order to break free of the host cell that made them.