Placeholder image of a protein
Icon representing a puzzle

420: Mini Protein Puzzle 2: Ebola Ligand

Closed since almost 15 years ago

Intermediate Overall Prediction

Summary

Created
May 13, 2011
Expires
Max points
100
Description

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 8,824
  2. Avatar for Void Crushers 2. Void Crushers 80 pts. 8,812
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 63 pts. 8,812
  4. Avatar for foldeRNA 4. foldeRNA 49 pts. 8,812
  5. Avatar for Go Science 5. Go Science 37 pts. 8,790
  6. Avatar for SETI.Germany 6. SETI.Germany 28 pts. 8,757
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 21 pts. 8,750
  8. Avatar for Deleted group 8. Deleted group pts. 8,725
  9. Avatar for Deleted group 9. Deleted group pts. 8,706
  10. Avatar for Deleted group 10. Deleted group pts. 8,706
  1. Avatar for Ch Garnier 81. Ch Garnier Lv 1 9 pts. 8,635
  2. Avatar for dglion 82. dglion Lv 1 9 pts. 8,632
  3. Avatar for weitzen 83. weitzen Lv 1 9 pts. 8,632
  4. Avatar for deus911 84. deus911 Lv 1 8 pts. 8,629
  5. Avatar for Deleted player 85. Deleted player pts. 8,627
  6. Avatar for feet1st 86. feet1st Lv 1 8 pts. 8,626
  7. Avatar for Shelena 87. Shelena Lv 1 7 pts. 8,626
  8. Avatar for Thallium 88. Thallium Lv 1 7 pts. 8,625
  9. Avatar for miss wanr 89. miss wanr Lv 1 7 pts. 8,624
  10. Avatar for themarquis 90. themarquis Lv 1 7 pts. 8,622

Comments

beta_helix Staff Lv 1

This tiny domain is an independently-folding piece of a larger ubiquitin ligase protein, responsible for tagging proteins with ubiquitin (also a protein) thereby marking them for death.

This particular ubiquitin ligase is capable of binding and tagging viral proteins - but this turns out to be a bad thing, as certain viruses (like Ebola) need to have ubiquitin attached to one of their proteins in order to break free of the host cell that made them.